Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental models in primates for reconstructive surgery utilizing tissue transplants.

E P Egerszegi, D D Samulack, R K Daniel

    Annals of Plastic Surgery
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Endoscopic forehead lift.

    Aesthetic surgery journal·2009
    Same author

    Endoscopic forehead lift: anatomic basis.

    Aesthetic surgery journal·2009
    Same author

    Rhinoplasty: large nostril/small tip disproportion.

    Plastic and reconstructive surgery·2001
    Same author

    Superior eyelid incision: an alternative approach for frontozygomatic dermoid cyst excision.

    Annals of plastic surgery·2000
    Same author

    Rhinoplasty: a simplified, three-stitch, open tip suture technique. Part I: primary rhinoplasty.

    Plastic and reconstructive surgery·1999
    Same author

    Rhinoplasty: a simplified, three-stitch, open tip suture technique. Part II: secondary rhinoplasty.

    Plastic and reconstructive surgery·1999

    Researchers developed primate models for tissue transplantation, achieving prolonged survival using high-dose cyclosporin A and steroids. Ongoing studies focus on nerve regeneration in these complex transplants.

    Area of Science:

    • Primate models
    • Transplantation biology
    • Immunosuppression

    Background:

    • Developing experimental models for primate tissue transplantation is crucial for advancing regenerative medicine.
    • Studying reinnervation processes in transplanted tissues requires robust survival models.

    Observation:

    • Two models were created: a neurovascular free flap of the index finger and an entire hand transplant.
    • High-dose cyclosporin A combined with a tapering steroid regimen facilitated prolonged survival in both models.

    Findings:

    • The immunosuppressive protocol (cyclosporin A and steroids) effectively supports long-term survival of primate tissue transplants.
    • Close monitoring of biochemical, hematological, and drug levels enables safe high-dose immunosuppression in primates.

    Related Experiment Videos

    Implications:

    • These models provide a foundation for future research into nerve regeneration and functional recovery after transplantation.
    • The findings support the potential for complex tissue and limb transplantation in primates, paving the way for clinical applications.