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Prospective randomized double-blind comparison of nephrotoxicity and auditory toxicity of tobramycin and netilmicin
Abstract:
Netilmicin or tobramycin was administered to 197 patients in a prospective randomized double-blind trial. Of these patients, 140 recipients of nine or more doses of netilmicin or tobramycin could be evaluated for nephrotoxicity. Fifty-five patients were able to cooperate in the administration of serial audiograms. Nephrotoxicity of similar severity developed in 7 of 73 (9.6%) recipients of tobramycin and in 7 of 67 (10.4%) recipients of netilmicin (P greater than 0.05). Mild or slight auditory toxicity developed in 5 of 28 (17.8%) recipients of tobramycin and in 2 of 27 (7.4%) recipients of netilmicin (P greater than 0.05).
Insights
This study compared netilmicin and tobramycin in patients, finding similar rates of nephrotoxicity and auditory toxicity between the two antibiotics. Both drugs demonstrated comparable safety profiles in the evaluated patient groups.
Area of Science:
- Pharmacology
- Nephrology
- Ototoxicology
Background:
- Aminoglycosides like netilmicin and tobramycin are crucial in treating severe bacterial infections.
- Monitoring for adverse effects, particularly nephrotoxicity and auditory toxicity, is essential for patient safety.
Purpose of the Study:
- To compare the incidence and severity of nephrotoxicity and auditory toxicity between netilmicin and tobramycin.
- To evaluate the safety profiles of these two commonly used aminoglycoside antibiotics in a clinical setting.
Main Methods:
- A prospective, randomized, double-blind trial involving 197 patients.
- Evaluation of nephrotoxicity in 140 patients receiving nine or more doses.
- Assessment of auditory toxicity through serial audiograms in 55 cooperating patients.
Main Results:
- Nephrotoxicity occurred in 9.6% of tobramycin recipients and 10.4% of netilmicin recipients (P > 0.05).
- Mild auditory toxicity was observed in 17.8% of tobramycin recipients and 7.4% of netilmicin recipients (P > 0.05).
Conclusions:
- Netilmicin and tobramycin exhibit similar rates of nephrotoxicity.
- Auditory toxicity incidence was comparable between the two antibiotics, with no statistically significant difference.