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Related Experiment Videos

Prophylactic antibiotics in appendicectomy: a prospective double blind randomized study.

M G O'Rourke, J M Wynne, R J Morahan

    The Australian and New Zealand Journal of Surgery
    |December 1, 1984
    PubMed
    Summary

    Comparing intravenous cefoxitin and rectal metronidazole for appendicectomy prophylaxis, this study found no significant difference in outcomes. Both methods showed a 6% minor wound infection rate, supporting short-course antibiotic prophylaxis.

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    Area of Science:

    • Surgical Infection Prophylaxis
    • Clinical Trial Methodology
    • Microbiology

    Background:

    • Appendicectomy is a common surgical procedure.
    • Surgical site infections (SSIs) are a potential complication.
    • Antibiotic prophylaxis is standard practice to reduce SSIs.

    Purpose of the Study:

    • To compare the efficacy of intravenous cefoxitin versus rectal metronidazole for antibiotic prophylaxis in appendicectomy.
    • To evaluate the incidence and severity of wound infections.
    • To assess the bacteriologic profile of the appendix.

    Main Methods:

    • Double-blind, prospective, randomized controlled trial.
    • Participants received either intravenous cefoxitin or rectal metronidazole.
    • Wound infections were monitored post-discharge.

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    Main Results:

    • No significant difference in outcomes between the two prophylactic groups.
    • Overall wound infection rate was 6%, with most occurring after hospital discharge.
    • Bacteriology revealed similar flora in normal and inflamed appendices, suggesting comparable infection risks.

    Conclusions:

    • Short-course antibiotic prophylaxis is supported for appendicectomy.
    • Intravenous cefoxitin offers certainty but at a higher cost than rectal metronidazole.
    • The findings suggest similar infection risks for both inflamed and non-inflamed appendicectomies.