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Cortisone induced bone changes and its response to lipid clearing agents
Clinical Orthopaedics and Related Research
|January 1, 1978
Summary
Cortisone increases serum cholesterol and causes fatty changes in rabbit tissues. Clofibrate therapy may mitigate these cortisone-induced effects, potentially improving femoral head microcirculation.
Area of Science:
- Biomedical research
- Pharmacology
- Histopathology
Background:
- Cortisone administration is known to affect various organs.
- Potential adverse effects of cortisone on bone and lipid metabolism require investigation.
Purpose of the Study:
- To investigate the effects of cortisone on rabbit bone, lungs, kidneys, and liver.
- To evaluate the potential modifying effects of clofibrate therapy on cortisone-induced changes.
Main Methods:
- Experimental study involving thirty-two rabbits.
- Administration of cortisone and clofibrate.
- Analysis of serum cholesterol, liver, and femoral head tissues.
Main Results:
- Cortisone induced elevated serum cholesterol, liver fatty metamorphosis, and femoral head microvascular fatty emboli.
- Clofibrate therapy demonstrated a reduction in serum cholesterol and mitigated increases in marrow fat cell size.
- These findings suggest a potential improvement in femoral head microcirculation.
Conclusions:
- Cortisone causes significant adverse effects on lipid metabolism and tissue microcirculation in rabbits.
- Clofibrate therapy may offer a protective effect against cortisone-induced pathology.
- Further research is warranted to explore clofibrate's therapeutic potential in managing cortisone-related complications.