Anaesthetic management in experimental orthotopic liver transplantation in the pig

Anaesthesiological experiences are described with 103 porcine orthotopic liver transplantations. The animals were operated in neurolept anaesthesia. After premedication and induction, fentanyl and pancuronium were administered as a continuous infusion until hepatectomy was completed. Haemodynamic and metabolic changes during the procedure were monitored. Metabolic acidosis should be avoided by administration of sodium bicarbonate before declamping. Corrections of alterations in serum electrolytes and in blood glucose levels seem to be unnecessary. These above-mentioned observations have led to a safe anaesthetic procedure and management in experimental orthotopic liver transplantation.