Age changes of chromatin. A review

The age-related studies of chromatin and DNA has attracted significant interest in recent years. However, individual works describe only some and a few of the many changes of chromatin. It is often difficult to decide whether these changes have secondary or primary nature. The overview of these studies makes it possible to realize how many very complex and interdependent changes occur in chromatin during ageing. Chromatin is the most complex among self-reproducible parts of the cell. A very sophisticated structure of chromatin makes possible the differential transcription of a genetic programme which supports the accurate specialized functions of each cell in interphase and also provides a mechanism for perfect reproduction of this complex machinery of genetic information during cell division. It is known that chromatin proteins, more than chromatin DNA show tissue specificity and developmental changes. There are many theories of cellular ageing which select some special types of DNA, RNA or protein changes and to promote them as the main or primary causes of cellular senescence. However, if these changes are considered within the more comprehensive picture of functional structure of chromatin the results show the interdependence of individual alterations and their proper place in the complex, multichannel, species and tissue-specific character of actual ageing. An attempt to summarize the basic facts and theories about age changes of the two main parts of chromatin structure, proteins and DNA is being made in this review. At the same time the author tried to develop a concept of non-random distribution of the age changes in chromatin and a possible higher rate of accumulation of different alteration and lesions in the transcribed and functionally active parts of chromatin.