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Updated: Aug 2, 2026

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
Published on: January 2, 2013
Effects of immune complexes on immunity to Plasmodium berghei infection
Abstract:
The ELISA test titers and RIPA patterns of sera collected from vaccinated and non-vaccinated rats during P. berghei infection were similar. The sera collected just after clearance of parasitemia from the vaccinated rats, but not that from the non-vaccinated rats protected mice in passive protection tests. After precipitation to remove immune complexes, the sera from the non-vaccinated rats also protected mice. Administration of acute phase serum early in the course of infection aggravated parasitemia and delayed recovery from P. berghei infection in rats. Administration of hyperimmune serum early in the course of infection initially reduced parasitemia but then delayed recovery of rats from P. berghei infection. These results suggest that immune complexes may interfere with antibody mediated immunity to P. berghei and may also retard development of the induced immune response.
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