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Trazodone. A comparative clinical and predictive study.

T A Kerr, H A McClelland, D A Stephens

    Acta Psychiatrica Scandinavica
    |December 1, 1984
    PubMed
    Summary
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    Trazodone and amitriptyline effectively treat depression, with similar antidepressant action. Trazodone showed fewer side effects like dry mouth and psychiatric reactions compared to amitriptyline.

    Area of Science:

    • Psychiatry
    • Clinical Pharmacology

    Background:

    • Depressive illness is a significant mental health concern requiring effective pharmacotherapy.
    • Trazodone and amitriptyline are established antidepressants with distinct mechanisms of action and side effect profiles.

    Purpose of the Study:

    • To compare the clinical efficacy and tolerability of trazodone and amitriptyline in hospitalized patients with depressive illness.
    • To evaluate the effectiveness of these antidepressants across different depression subtypes.

    Main Methods:

    • A comparative study involving 74 hospital patients diagnosed with depressive illness.
    • Patients received daily doses of trazodone (150-300 mg) or amitriptyline (75-225 mg), with dose adjustments for older adults.
    • Antidepressant activity was assessed over 6 weeks using validated scales: Hamilton Depression Rating Scale (HDRS), Zung Scale, visual analogue scales, and Global Assessment Scale.

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    Main Results:

    • Both trazodone and amitriptyline demonstrated significant antidepressant efficacy, with no statistically significant difference between the two drugs.
    • Patients with neurotic or endogenous depression responded similarly to both trazodone and amitriptyline.
    • Trazodone was associated with a more favorable tolerability profile, exhibiting fewer instances of persistent dry mouth and severe adverse psychiatric reactions compared to amitriptyline.

    Conclusions:

    • Trazodone and amitriptyline are equally effective in treating depressive illness.
    • Trazodone may offer a better tolerability profile, particularly regarding dry mouth and psychiatric adverse effects, making it a potentially preferable option for some patients.
    • Patient-specific factors and side effect profiles should guide the selection between trazodone and amitriptyline for depression management.