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Nonhuman primate models for human disease.

H M McClure

    Advances in Veterinary Science and Comparative Medicine
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Nonhuman primates serve as critical models for human diseases, including bacterial and degenerative conditions. Studying these spontaneous and induced diseases in primates offers valuable insights for human treatment and understanding.

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    Area of Science:

    • Veterinary Medicine
    • Comparative Pathology
    • Primate Models

    Background:

    • Nonhuman primates are established models for numerous human infectious diseases.
    • They are often uniquely susceptible to experimental human pathogens.
    • Spontaneous diseases in primates frequently mirror human conditions.

    Purpose of the Study:

    • To review spontaneous and induced nonhuman primate diseases with human counterparts.
    • To highlight their value in studying human disease etiology, pathogenesis, and treatment.
    • To identify potential new models for degenerative and genetic diseases.

    Main Methods:

    • Review of literature on spontaneous and induced nonhuman primate diseases.
    • Comparison of clinical and pathological features with human diseases.

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  • Identification of diseases with direct human parallels.

    • Main Results:

    • Four spontaneous and one induced nonhuman primate disease were reviewed.
    • These included three bacterial diseases and one degenerative disease comparable to human conditions.
    • One potential genetic disease model lacking a current animal counterpart was identified.

    Conclusions:

    • Nonhuman primate diseases provide valuable models for serious human conditions.
    • Clinical and pathological similarities underscore their utility for research.
    • Further investigation of these models can advance understanding and treatment of human diseases.