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Related Experiment Videos

Gastrointestinal and dermal absorption: interspecies differences.

E J Calabrese

    Drug Metabolism Reviews
    |January 1, 1984
    PubMed
    Summary
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    Human skin absorption varies significantly between species. While pigs and monkeys closely mimic human dermal absorption, more research is needed to confirm these findings across diverse chemical compounds.

    Area of Science:

    • Toxicology
    • Dermal Absorption Studies
    • Comparative Physiology

    Background:

    • Significant interspecies differences exist in dermal absorption of diverse chemical substances.
    • Substances of environmental/occupational health relevance, like organophosphate insecticides, show varied skin penetration across species.
    • Human skin is generally less permeable than rabbit and rodent skin.

    Purpose of the Study:

    • To evaluate interspecies differences in dermal absorption.
    • To identify animal models that best simulate human dermal absorption.
    • To determine if current data supports broad conclusions on species-specific absorption.

    Main Methods:

    • Review of existing studies on dermal absorption across different species.
    • Comparison of permeability data for various chemical classes.

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  • Assessment of the representativeness of tested substances for broad conclusions.

    • Main Results:

    • Pig and monkey skin show absorption capabilities most similar to human skin.
    • Human skin demonstrates lower permeability compared to rabbit and rodent skin for tested substances.
    • Existing data, though consistent, may not cover a sufficiently representative range of compounds.

    Conclusions:

    • While pigs and monkeys are promising models, further systematic evaluations are required.
    • Current data suggests significant interspecies variability in dermal absorption.
    • Broader research across diverse chemical classes is necessary to draw definitive conclusions on dermal absorption differences.