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Influence of naloxone on the captopril-induced decrease in vagal pressor reflexes.

P Montastruc, J L Montastruc, G Gaillard-Plaza

    Journal De Pharmacologie
    |October 1, 1984
    PubMed
    Summary
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    Intracisternal captopril reduces blood pressure responses to vagal stimulation in dogs. This effect, mediated by central opioid mechanisms, was reversed by naloxone, indicating a role for opioids in captopril's hypotensive action.

    Area of Science:

    • Cardiovascular Physiology
    • Neuropharmacology

    Background:

    • The renin-angiotensin system plays a crucial role in blood pressure regulation.
    • Captopril is an angiotensin-converting enzyme (ACE) inhibitor with known antihypertensive effects.

    Purpose of the Study:

    • To investigate the central mechanisms underlying the hypotensive effects of captopril.
    • To explore the involvement of central opioid pathways in captopril's action on blood pressure regulation.

    Main Methods:

    • Anesthetized dogs were utilized as the experimental model.
    • Intracisternal injections of captopril were administered.
    • Afferent stimulation of the vagus nerve was performed to elicit pressor responses.
    • Intravenous injections of naloxone were used to assess opioid receptor involvement.

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    Main Results:

    • Intracisternal captopril administration significantly decreased the pressor responses to vagal nerve stimulation.
    • The hypotensive effect of captopril was reversed by the subsequent administration of naloxone.
    • These findings indicate that central opioid mechanisms are involved in captopril's blood pressure-lowering effects.

    Conclusions:

    • Captopril exerts hypotensive effects through central mechanisms.
    • Central opioid pathways are implicated in the blood pressure-regulating actions of captopril.
    • Further research into the interaction between ACE inhibitors and the central opioid system is warranted.