[Action of iron, ethanol and tetrachloromethane on lysosomal membrane permeability]

The authors examined the isolated and combined influence of oral administration of iron and ethanol as well as subcutaneous administration of CCl4 on the activity of two lysosomal enzymes in serum as the experiments were carried out on 72 male white rats of the Wistar strain with initial weight of 130 to 190 gm. The two exmained enzymes were: beta-N-acethylglucosaminidase and alpha-manosidase. The increased activity of these enzymes under the action of ethanol, iron plus ethanol, CCl4 was interpreted as a manifestation of increased permeability of lysosomal cellular membrane.