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[Vascular factors in the pathogenesis of pre-eclampsia: recent findings]

J M Foidart, R Lambotte

    Revue Francaise De Gynecologie Et D'Obstetrique
    |April 1, 1984
    PubMed

    Normal, rigid and fibrotic utero-placental arteries are resistant to the action of circulating vaso-motor substances. In contrast, the persistence and the hyperplasia of smooth muscle fibres result in a reduced flow in the intervillous compartment and a sensitivity of the vessels to vaso-constrictor substances. These lesions, which develop after the twentieth week, provide the necessary conditions for the subsequent development of the characteristic vicious cycles of eclampsia.

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