Intrastromal crystalline deposits following corneal graft rejection

Five patients were noted to develop fine crystals in the corneal stroma following rejection of corneal grafts. Four had penetrating, and one lamellar, keratoplasty. All recovered from rejection after steroid therapy. The crystals were fine, gray to tan, refractile, not associated with visual loss, and stable over several months of follow-up. We speculate that these crystals may be related to immune globulin or immune complex deposition, although they may be lipid left after resolution of inflammatory infiltrate.