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What makes wild rabbits drink?

E Tarjan, D A Denton, M J McKinley

    Journal De Physiologie
    |January 1, 1984
    PubMed
    Summary
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    Angiotensin II (AII) infusion in wild rabbits stimulated salt appetite and increased sodium excretion, but did not affect water intake. These findings reveal insights into salt and water balance regulation in these invasive mammals.

    Area of Science:

    • Physiology
    • Animal Ecology
    • Neuroendocrinology

    Background:

    • Wild rabbits (Oryctolagus cuniculus) are invasive mammals in Australia, inhabiting diverse environments with varying water and salt availability.
    • Understanding their physiological adaptations is crucial for managing invasive species and ecological impacts.

    Purpose of the Study:

    • To investigate the effects of intracerebroventricular (IVT) infusion of angiotensin II (AII) on water and salt intake in wild rabbits.
    • To determine the role of AII in regulating sodium balance and appetite in this species.

    Main Methods:

    • Wild rabbits were maintained under laboratory conditions and adapted to a dry diet.
    • Intracerebroventricular infusions of AII (10, 50, 500 ng/h) or sodium-lacking cerebrospinal fluid (Na-CSF) were administered.

    Related Experiment Videos

  • Water and salt (0.5 M NaCl) intake, urinary sodium excretion, and sodium balance were monitored.

    • Main Results:

    • IVT AII infusion did not increase water intake but significantly enhanced salt appetite, with a delay of 1-2 days.
    • High-dose AII (500 ng/h) temporarily reduced water intake and increased sodium excretion tenfold.
    • Lower doses of AII (10 ng/h) for five days progressively increased sodium excretion and salt appetite, which persisted after infusion cessation.

    Conclusions:

    • Angiotensin II plays a significant role in stimulating salt appetite and regulating sodium excretion in wild rabbits.
    • Despite unchanged water intake, AII influences sodium balance, suggesting complex regulatory mechanisms in these invasive animals.
    • These findings contribute to understanding the physiological basis of wild rabbit adaptation and persistence in Australia.