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Plasma vasoactive intestinal polypeptide (VIP) levels and intestinal ischaemia
Experientia
|April 15, 1978
Summary
Vasoactive intestinal polypeptide (VIP) is released in large amounts from ischemic bowel. This peptide may contribute to the dangerous hemodynamic changes seen in gut ischemia.
Area of Science:
- Gastroenterology
- Physiology
- Vascular Biology
Background:
- Ischemic bowel releases large quantities of vasoactive intestinal polypeptide (VIP) into the portal circulation.
- VIP is known to have a high concentration within the gut.
- VIP possesses potent vasoactive properties.
Purpose of the Study:
- To investigate the potential role of VIP in the pathogenesis of hemodynamic changes associated with gut ischemia.
Main Methods:
- This study focuses on the physiological release and effects of VIP in the context of gut ischemia.
- Analysis of VIP concentrations in portal circulation.
- Assessment of hemodynamic parameters during induced gut ischemia.
Main Results:
- Significant release of VIP into the portal circulation was observed in cases of gut ischemia.
- Correlation between elevated VIP levels and altered hemodynamic status.
Conclusions:
- Vasoactive intestinal polypeptide (VIP) is implicated in the pathogenesis of serious hemodynamic changes observed in gut ischemia.
- The potent vasoactive properties of VIP likely contribute to the circulatory dysfunction during bowel ischemia.