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Updated: Aug 15, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
Published on: June 27, 2015
Interactions of renin, kinins and prostaglandins
Abstract:
Resetting of the 'pressure-natriuresis' balance may result from subtle changes in renal vascular resistance or an independent defect in sodium excretion. The renin-angiotensin system, renal kinins and prostaglandins are all implicated in the regulation of glomerular filtration rate (GRF), renal blood flow (RBF) and urinary sodium excretion. Experimental and clinical evidence is reported demonstrating intimate, but poorly understood, interactions between these systems. Locally synthetized vasodilatory hormones (kinins, prostaglandins) modulate the effects of angiotensin II (AII), norepinephrine and alpha-adrenergic stimuli on renal vasculature and sodium excretion. It is suggested that an alteration of this interplay may be responsible for some forms of experimental and human hypertension.
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