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Candida albicans transmission by penetrating keratoplasty

Cornea
|January 1, 1984
PubMed

Insights

Corneal transplant infections are a risk. A case of Candida albicans endophthalmitis occurred after transplanting a donor eye with positive fungal cultures, highlighting the need for antifungal screening.

Area of Science:

  • Ophthalmology
  • Microbiology
  • Transplantation

Background:

  • Microbial transmission during penetrating keratoplasty poses a risk to corneal transplant recipients.
  • Eye banks commonly use antibiotics/antiseptics for donor eye preparation, but antifungal prophylaxis is not standard.
  • Fungal infections, such as Candida albicans endophthalmitis, remain a concern in corneal transplantation.

Observation:

  • A case of Candida albicans endophthalmitis developed post-penetrating keratoplasty.
  • The donor eye used in this case tested positive for Candida cultures prior to transplantation.
  • Standard antibiotic/antiseptic pretreatment did not prevent fungal transmission.

Findings:

  • Donor eye microbial status is critical for preventing post-transplant infections.
  • The presence of Candida in donor cultures can lead to severe intraocular infection.
  • Current donor eye decontamination protocols may not adequately address fungal pathogens.

Implications:

  • Routine antifungal screening of donor corneas may be warranted to prevent endophthalmitis.
  • Enhanced decontamination protocols for donor eyes should be considered to include antifungal agents.
  • Surgeons and eye banks must be vigilant for fungal contamination in corneal donors to improve patient outcomes.

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