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Pregnancy alters diurnal variation of plasma glucose concentration
1Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Human pregnancy introduces a diurnal variation of fasting plasma glucose concentrations, with significantly lower values found after a daytime fast of eight hours compared with a night-time fast of the same duration. The diurnal variation of plasma glucose clearance, found in nonpregnant subjects, is not demonstrable during pregnancy. Insulin tolerance does not exhibit a circadian valuation but is substantially decreased during pregnancy.
Human pregnancy introduces a diurnal variation of fasting plasma glucose concentrations, with significantly lower values found after a daytime fast of eight hours compared with a night-time fast of the same duration. The diurnal variation of plasma glucose clearance, found in nonpregnant subjects, is not demonstrable during pregnancy. Insulin tolerance does not exhibit a circadian valuation but is substantially decreased during pregnancy.