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Biomolecular-solvent stereodynamic coupling probed by deuteration.

S L Fornili¹, M Leone, F Madonia

¹Dept. of Physics, University of Palermo, Italy.

Journal of Biomolecular Structure & Dynamics

|October 1, 1983

Summary

Solvent stereodynamics, or the spatial arrangement of solvent molecules, is crucial for biomolecule stability. Perturbing solvent structure impacts these pathways, influencing biomolecular thermodynamics and function.

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Area of Science:

Biophysical Chemistry
Chemical Physics
Molecular Biophysics

Background:

The structure of aqueous solvent and its stereodynamic configurations are understood to possess identifiable topologic and order properties.
Solvent stereodynamics is increasingly recognized for its role in the thermodynamic stability of biomolecules.

Purpose of the Study:

To explore the thermodynamic interpretation of experiments involving isotopically perturbed solvents.
To establish the direct relevance of solvent stereodynamics to biomolecular thermodynamic stability.

Main Methods:

Utilizing isotopic substitution to perturb solvent structure.
Analyzing the effects of co-solvents on solvent topologic structures.
Developing a microscopic model for thermodynamic interpretation.

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Main Results:

Experiments with isotopically perturbed solvents support the link between solvent stereodynamics and biomolecular stability.
Perturbing solvent connectivity pathways (via isotopic substitution or co-solvents) affects their topologic structures.
The microscopic model provides a clear visualization of thermodynamic interpretations.

Conclusions:

Topologic stereodynamic structures of solvent connectivity pathways gain thermodynamic and biological significance through solute interactions.
The study frames the problem of biomolecular thermodynamic and functional stability within the context of solvent structure and dynamics.