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Amino acids and respiration.

C Weissman, J Askanazi, S Rosenbaum

Annals of Internal Medicine

|January 1, 1983

Summary

This summary is machine-generated.

Parenteral nutrition with amino acids quickly restores respiration and metabolic rate suppressed by glucose infusions. Amino acids enhance ventilatory drive, improving breathing function within hours.

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Area of Science:

Metabolic and Respiratory Physiology
Nutritional Support
Clinical Investigation

Background:

Parenteral nutrition (PN) solutions containing glucose and amino acids are used clinically.
The impact of PN components on respiratory function requires detailed investigation.

Purpose of the Study:

To determine the effects of prolonged dextrose infusion and subsequent amino acid infusion on respiratory parameters in healthy subjects.

Main Methods:

Eight healthy subjects received 7-day infusion of 5% dextrose followed by 24-hour infusion of 3.5% amino acids.
Measurements included minute ventilation (VE), tidal volume, oxygen consumption, and carbon dioxide production.

Main Results:

Dextrose infusion significantly depressed VE, oxygen consumption, and carbon dioxide production.
Amino acid infusion rapidly increased VE, metabolic rate, and tidal volume (VT/VI), indicating enhanced neuromuscular ventilatory drive.

Conclusions:

Amino acids effectively reverse respiratory depression caused by prolonged dextrose PN.
Amino acids rapidly restore metabolic rate, minute ventilation, and ventilatory drive within hours of administration.