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Related Experiment Videos

Nifedipine in hypertensive emergencies.

O Bertel, D Conen, E W Radü

    British Medical Journal (Clinical Research Ed.)
    |January 1, 1983
    PubMed
    Summary

    Oral nifedipine effectively lowers very high blood pressure in emergencies. This safe treatment also increased cerebral blood flow, unlike clonidine, making it a valuable option for hypertensive emergencies.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Neurology

    Background:

    • Hypertensive emergencies require rapid blood pressure reduction.
    • Existing treatments may have limitations or require intensive monitoring.

    Purpose of the Study:

    • To evaluate the efficacy and safety of oral nifedipine for acute antihypertensive treatment.
    • To investigate the impact of oral nifedipine on cerebral blood flow compared to intravenous clonidine.

    Main Methods:

    • A single-blind, placebo-controlled study involving 25 patients with severe hypertension.
    • Cerebral blood flow assessment using xenon-133 in a subgroup of 10 patients.
    • Random allocation to oral nifedipine or intravenous clonidine for comparison.

    Main Results:

    • Oral nifedipine significantly reduced systolic and diastolic blood pressure within 30 minutes (p < 0.001).
    • A significant increase in heart rate was observed, inversely related to patient age (p < 0.01).
    • Oral nifedipine increased cerebral blood flow in most patients, while clonidine decreased it by up to 28%.

    Conclusions:

    • Oral nifedipine is an effective and safe option for managing hypertensive emergencies.
    • Nifedipine's positive effect on cerebral blood flow offers an advantage over clonidine.
    • This treatment is particularly suitable when continuous patient monitoring is challenging.

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