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[Primary aspergillosis of the lung in leukoses]
Abstract:
The course, radiological features and pathological changes of primary aspergillosis in four patients with acute lymphatic leukaemia are described. Two patients died despite antimycotic therapy. Breakdown of the infiltrate could not be established radiologically, nor pathologically. In a further two patients, a 'primary aspergilloma' developed during the course of several days. Both patients survived. The radiological demonstration of a fungus ball and of an air crescent in a typical aspergilloma can be regarded as a good prognostic sign.
Insights
Primary aspergillosis in acute lymphatic leukaemia patients presents varied outcomes. Radiological signs like fungus balls and air crescents in aspergillomas indicate a positive prognosis, aiding survival.
Area of Science:
- Medical Mycology
- Hematology
- Diagnostic Imaging
Background:
- Investigating primary aspergillosis in immunocompromised patients, specifically those with acute lymphatic leukaemia.
- Understanding the clinical course, radiological manifestations, and pathological findings of invasive fungal infections.
Observation:
- Describing four cases of primary aspergillosis in patients with acute lymphatic leukaemia.
- Documenting treatment responses, including antimycotic therapy, and patient outcomes.
- Analyzing radiological and pathological evidence of disease progression and resolution.
Findings:
- Two patients with acute lymphatic leukaemia and primary aspergillosis died despite treatment.
- In two other patients, a primary aspergilloma developed, and both survived.
- Radiological evidence of a fungus ball and air crescent in aspergilloma correlated with survival.
Implications:
- Highlights the diagnostic significance of specific radiological findings in aspergillosis.
- Suggests that the development of a radiologically confirmed aspergilloma may be a favorable prognostic indicator.
- Informs clinical management strategies for invasive fungal infections in leukaemia patients.