Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biological classification of depressive illness.

A Coppen, K Wood

    British Journal of Clinical Pharmacology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Results from the T2K Experiment on Neutrino Mixing Including a New Far Detector μ-like Sample.

    Physical review letters·2026
    Same author

    First Differential Measurement of the Single π^{+} Production Cross Section in Neutrino Neutral-Current Scattering.

    Physical review letters·2025
    Same author

    First Measurement of the Electron-Neutrino Charged-Current Pion Production Cross Section on Carbon with the T2K Near Detector.

    Physical review letters·2025
    Same author

    First Joint Oscillation Analysis of Super-Kamiokande Atmospheric and T2K Accelerator Neutrino Data.

    Physical review letters·2025
    Same author

    Measurements of neutrino oscillation parameters from the T2K experiment using <math><mrow><mn>3.6</mn><mo>×</mo><msup><mn>10</mn><mn>21</mn></msup></mrow></math> protons on target.

    The European physical journal. C, Particles and fields·2023
    Same author

    Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

    The European physical journal. C, Particles and fields·2022

    Biological markers for predicting antidepressant response are unreliable. Current tests for depression, including amine systems, thyrotropin-releasing hormone, growth hormone, and dexamethasone suppression, show limited diagnostic or predictive value for treatment outcomes.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Clinical Medicine

    Background:

    • Biological markers are explored to predict antidepressant treatment response in patients with depression.
    • Previous research suggested subtypes of depression based on noradrenaline or 5-hydroxytryptamine deficiencies, but selective antidepressants show similar efficacy.
    • Abnormalities in thyrotropin-releasing hormone and growth hormone secretion have been investigated as potential diagnostic indicators.

    Purpose of the Study:

    • To evaluate the utility of various biological criteria in refining clinical classification for predicting antidepressant treatment response.
    • To assess the diagnostic specificity and predictive value of neuroendocrine markers in depressive illness.

    Main Methods:

    • Review of existing literature on biological markers for depression.

    Related Experiment Videos

  • Analysis of studies investigating amine systems, thyrotropin-releasing hormone (TRH) response, growth hormone (GH) secretion, and the dexamethasone suppression test (DST) in depressed patients.

    • Main Results:

    • Selective amine reuptake inhibitors show similar therapeutic effects, and amine reuptake inhibition does not correlate with clinical outcome.
    • Thyrotropin-releasing hormone (TRH) response is not confirmed as specific for depressive illness; age and sex may influence findings.
    • Growth hormone (GH) response to stimuli has a predictive value of 53% for endogenous depression diagnosis.
    • The dexamethasone suppression test (DST) demonstrates high sensitivity but low specificity for endogenous depression, necessitating clinical correlation.

    Conclusions:

    • Current biological markers, including amine systems, TRH, GH, and DST, have limited reliability for predicting antidepressant response or diagnosing depression subtypes.
    • The dexamethasone suppression test (DST) should be used cautiously and in conjunction with clinical assessments due to its low specificity.
    • Further research is needed to identify reliable biological predictors for antidepressant treatment efficacy.