Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Initial experience with a physiological, rate responsive pacemaker.

R M Donaldson, K Fox, A F Rickards

    British Medical Journal (Clinical Research Ed.)
    |February 26, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Can We Miniaturize CT Technology for a Successful Mobile Stroke Unit Roll-Out?

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
    Same author

    Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts.

    Communications biology·2023
    Same author

    Tool for automatic macrozone characterization from EBSD data sets of titanium alloys.

    Journal of applied crystallography·2023
    Same author

    The Effects of a Perindopril-Based Regimen in Relation to Statin Use on the Outcomes of Patients with Vascular Disease: a Combined Analysis of the ADVANCE, EUROPA, and PROGRESS Trials.

    Cardiovascular drugs and therapy·2022
    Same author

    The impact of 10-valent pneumococcal vaccine introduction on invasive disease in Fiji.

    The Lancet regional health. Western Pacific·2022
    Same author

    Computerised decision support in veterinary medicine, exemplified in a canine idiopathic epilepsy care pathway.

    The Journal of small animal practice·2021
    Same journal

    Early retirement for consultants.

    British medical journal (Clinical research ed.)·2010
    Same journal

    From COMAR: Essential troika of teaching, research, and clinical care.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Parliament's two way pull on the NHS.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Conference Report: After the summit.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Council election: South Western regional vacancy 1988-90.

    British medical journal (Clinical research ed.)·2010
    Same journal

    Health managers support taxation based service.

    British medical journal (Clinical research ed.)·2010
    See all related articles

    A novel pacemaker adapts heart rate to metabolic needs using the QT interval. This physiological rate-responsive pacing significantly improves cardiac output and exercise capacity in patients.

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Physiology

    Background:

    • Conventional pacemakers often maintain a fixed heart rate, which may not adequately meet patients' physiological demands during activity.
    • The QT interval, a measure of ventricular repolarization, reflects autonomic nervous system activity and metabolic status.

    Purpose of the Study:

    • To evaluate a new pacemaker system that utilizes the QT interval to provide physiological rate-responsive pacing.
    • To assess the efficacy of QT interval-based pacing in adapting heart rate to metabolic requirements during exercise.

    Main Methods:

    • A novel pacemaker system was developed, employing the QT interval as an indicator of physiological demand.
    • Clinical evaluation was conducted in five patients, monitoring heart rate response during and after exercise.

    Related Experiment Videos

    Main Results:

    • The pacemaker demonstrated smooth and progressive rate adaptation to exercise.
    • Cardiac output increased by 45% compared to fixed-rate pacing.
    • Maximal exercise capacity improved by 57% compared to conventional pacing at 70 beats/min.

    Conclusions:

    • Physiological rate-responsive pacing using the QT interval is a viable method for optimizing heart rate.
    • This technology offers a simple approach to matching cardiac output with the body's metabolic needs.
    • QT interval-based pacing enhances exercise capacity and cardiac function in pacemaker patients.