Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic insulin resistance.

J K Davidson, D W DeBra

    Diabetes
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Sulfated beef insulin effectively controlled plasma glucose in patients with immunologic insulin resistance, showing reduced antigenicity and improved treatment response compared to regular insulin. This therapy offers a promising alternative for managing difficult-to-treat diabetes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary oil embolism following hysterosalpingography.

    The Journal of the Faculty of Radiologists. Faculty of Radiologists (Great Britain)·2014
    Same author

    The sexually experienced woman: Multiple sex partners and sexual satisfaction.

    Journal of sex research·2012
    Same author

    Induction of plant defense gene expression by plant activators and Pseudomonas syringae pv. tomato in greenhouse-grown tomatoes.

    Phytopathology·2008
    Same author

    Porous polyethylene implant fibrovascularization rate is affected by tissue wrapping, agarose coating, and insertion site.

    Ophthalmic plastic and reconstructive surgery·2000
    Same author

    Communicating with new sex partners: college women and questions that make a difference.

    Journal of sex & marital therapy·2000
    Same author

    Negative sinus pressure and normal predisease imaging in silent sinus syndrome.

    Archives of ophthalmology (Chicago, Ill. : 1960)·1999
    Same journal

    Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.

    Diabetes·2026
    Same journal

    Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.

    Diabetes·2026
    Same journal

    Targeting the ADA/ADO Axis Rescues β-Cell Failure in Type 2 Diabetes.

    Diabetes·2026
    Same journal

    TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence.

    Diabetes·2026
    Same journal

    Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.

    Diabetes·2026
    Same journal

    The Mechanism of TNF-α Combined With High Glucose in Regulating Calnexin Aggravates Endoplasmic Reticulum Stress in Endothelial Cell Injury of Diabetic Retinopathy.

    Diabetes·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Pharmacology

    Background:

    • Immunologic insulin resistance poses a significant challenge in diabetes management.
    • Patients often require high doses of conventional insulin, with limited efficacy.
    • Existing therapies like pork insulin or steroid treatment show variable success rates.

    Purpose of the Study:

    • To evaluate the efficacy of sulfated beef insulin in patients with immunologic insulin resistance.
    • To assess changes in insulin binding capacity and in vivo half-life during sulfated insulin therapy.
    • To compare the therapeutic response to sulfated insulin with other treatment modalities.

    Main Methods:

    • Studied 35 patients with immunologic insulin resistance previously treated with high-dose beef insulin.

    Related Experiment Videos

  • Administered sulfated beef insulin and monitored plasma glucose control.
  • Measured 125I-insulin binding capacity and in vivo half-life (T 1/2) before and after therapy.

    • Main Results:

    • Sulfated insulin therapy was successful in 34 out of 35 patients.
    • Mean insulin dose significantly decreased, and mean maximum binding capacity reduced (p < 0.01).
    • In vivo half-life of insulin improved significantly (p < 0.001), indicating reduced antigenicity.

    Conclusions:

    • Sulfated beef insulin is less antigenic and binds less avidly to antibodies than regular beef insulin.
    • Therapeutic response to sulfated insulin was superior to reported outcomes with pork insulin or steroid therapy.
    • Sulfated insulin represents a highly effective treatment option for patients with severe immunologic insulin resistance.