Evidence for an inverse relationship between the ventilatory response to exercise and the maximum whole body oxygen...

Ventilatory responses to submaximal exercise loads indicate that in a population of 895 physically active and sedentary male and female subjects, exercise ventilation is inversely related to predicted VO2max. The correlation coefficients for males and females in this relationship are 0.61 (P less than 0.0001) and 0.26 (P less than 0.0001) respectively. The slopes of regression lines for VE/VO2 and VO2max in female and male subjects are -2.59 and -0.91 respectively. This is associated with changes in composition of the expired air in that PCO2 increases and PO2 decreases with greater VO2max. The difference between the mean oxygen and carbon dioxide partial pressures in expired air of individuals in the highest and lowest VO2max ranges are 1.2 kPa (9 mm Hg) and 0.8 kPa (6 mm Hg) respectively.