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Leucocyte ascorbic acid in Crohn's disease.

R G Hughes, N Williams

    Digestion
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Patients with Crohn's disease have lower leucocyte ascorbic acid levels, likely due to the condition itself. Supplementing with ascorbic acid is recommended to address this deficiency.

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    Area of Science:

    • Biochemistry
    • Gastroenterology
    • Nutritional Science

    Background:

    • Crohn's disease is associated with various nutritional deficiencies.
    • Ascorbic acid (vitamin C) plays a crucial role in immune function and tissue repair.

    Purpose of the Study:

    • To investigate leucocyte ascorbic acid levels in Crohn's disease patients.
    • To determine if disease activity or treatment affects these levels.
    • To assess the appropriateness of ascorbic acid supplementation.

    Main Methods:

    • Comparison of leucocyte ascorbic acid levels between Crohn's disease patients and healthy controls.
    • Analysis to differentiate the cause of deficiency (disease vs. treatment).

    Main Results:

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    • Leucocyte ascorbic acid levels were significantly lower in Crohn's disease patients compared to controls.
    • The deficiency was attributed to the disease process, not drug or surgical treatments.

    Conclusions:

    • Crohn's disease patients exhibit a deficiency in ascorbic acid.
    • Supplementary ascorbic acid is a suitable intervention to correct this observed deficiency.