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Diseases transmitted by blood transfusion.

R A Kahn

    Human Pathology
    |March 1, 1983
    PubMed
    Summary

    Disease transmission via blood transfusion is rare, except for post-transfusion hepatitis (PTH). Reducing PTH requires careful donor screening and judicious blood product use while awaiting sensitive diagnostic tests.

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    Area of Science:

    • Transfusion Medicine
    • Infectious Disease Transmission
    • Hepatology

    Background:

    • Blood transfusions are generally safe, with limited documented disease transmission.
    • Post-transfusion hepatitis (PTH) remains a significant concern.
    • Other transfusion-transmitted infections include malaria, parasitic diseases, syphilis, and bacterial infections.

    Purpose of the Study:

    • To review the risks of disease transmission through blood transfusion.
    • To highlight the importance of addressing post-transfusion hepatitis (PTH).
    • To suggest interim strategies for reducing PTH incidence.

    Main Methods:

    • Review of existing case reports and medical literature.
    • Analysis of disease transmission patterns in transfusion medicine.
    • Discussion of diagnostic and preventive measures for transfusion-transmitted infections.

    Main Results:

    • Except for PTH, disease transmission via blood transfusion is infrequent.
    • Effective eradication of PTH hinges on developing sensitive and specific tests for non-A, non-B agents.
    • Current strategies to mitigate PTH risk include careful donor selection and appropriate use of blood components.

    Conclusions:

    • Blood transfusion safety is high, with PTH being the primary exception.
    • Development of diagnostic tests for non-A, non-B hepatitis agents is crucial for eradicating PTH.
    • Prudent blood donor recruitment and judicious use of blood products are essential interim measures to reduce PTH incidence.

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