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[Trehalose-load test in gastroenterology].

U Rodeck, H C Dominick

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |January 1, 1983
    PubMed
    Summary
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    Trehalose-load tests and disaccharidase activities in infants show varying correlation with intestinal mucosa morphology. Trehalase activity better reflects histological findings than lactase activity or trehalose-load tests.

    Area of Science:

    • Pediatric Gastroenterology
    • Histopathology
    • Enzymology

    Context:

    • Infant intestinal mucosa assessment involves evaluating morphology and function.
    • Disaccharide malabsorption is a common concern in pediatric gastrointestinal disorders.

    Purpose:

    • To investigate the correlation between intestinal mucosal morphology and functional tests (trehalose-load test, disaccharidase activities) in infants.
    • To compare the diagnostic utility of trehalase and lactase activities against trehalose-load tests in reflecting mucosal damage.

    Summary:

    • Histological examination of intestinal biopsies from 35 infants was correlated with trehalose-load tests and enzyme activities (trehalase, lactase).
    • Correlation between functional tests/enzyme activities and mucosal morphology varied with the severity of damage, being weaker in moderate damage and stronger in absent or severe damage.

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  • Trehalase activity demonstrated a better correlation with histological findings than lactase activity or the trehalose-load test.

    • Impact:

    • Provides insights into the reliability of different diagnostic methods for assessing infant intestinal mucosal health.
    • Suggests trehalase activity may be a more sensitive indicator of histological changes in the infant intestinal mucosa compared to other methods.
    • Informs clinical practice regarding the choice of diagnostic tools for evaluating pediatric gastrointestinal conditions.