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Updated: Aug 29, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
The effect of irradiation on platelet arachidonic acid metabolism
Abstract:
Irradiation of platelets in vitro to 2000 rads did not alter arachidonic acid metabolism through the cyclooxygenase pathway. Production of platelet thromboxane B2 and 12-hydroxy-5,8-10-heptadecatrienoic acid remained similar in control and paired irradiated platelets. In paired samples the platelet lipoxygenase metabolite 12-hydroxy-5,8,10,14-eicosatetraenoic acid was significantly increased postirradiation to 42 +/- 2.8 percent when compared to a control value of 34.1 +/- 3.6 percent (p less than 0.02). Although this latter product has been demonstrated to be chemotactic for neutrophils, its role in platelet function has not been specifically determined.
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