Lymph node enlargement due to amyloid

A case of a patient presenting with supraclavicular and cervical lymph node enlargement with demonstration of amyloid is presented. Histologic features are described. Amyloid deposition was not found in any other organ. Immunohistochemical typing with antisera raised against protein AA, A lambda, and A kappa showed a reaction only against A lambda. Thus, this case belongs to the immunoglobulin lambda light chain-derived types that occur in many other parts of the body, particularly the respiratory tract.