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Lymph node enlargement due to amyloid.

J R Newland, R P Linke, O Kleinsasser

    Virchows Archiv. A, Pathological Anatomy and Histopathology
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    This case study details a patient with enlarged lymph nodes showing amyloid deposits. The amyloid was identified as lambda light chain-derived, a type also found in the respiratory tract.

    Area of Science:

    • Pathology
    • Immunohistochemistry
    • Medical Case Reports

    Background:

    • Amyloidosis is a group of diseases characterized by amyloid deposition in various organs.
    • Lymph node enlargement can be a presenting symptom of systemic or localized amyloidosis.
    • Immunohistochemistry is crucial for classifying amyloid types based on precursor proteins.

    Observation:

    • A patient presented with enlarged supraclavicular and cervical lymph nodes.
    • Histological examination confirmed amyloid deposition within the lymph nodes.
    • Amyloid deposits were localized exclusively to the lymph nodes, with no evidence in other organs.

    Findings:

    • Immunohistochemical analysis identified the amyloid as derived from immunoglobulin lambda light chains (A lambda).

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  • Reactions against protein AA and A kappa were negative.
  • This specific amyloid type is known to occur in other body sites, notably the respiratory tract.

    • Implications:

    • This case highlights the importance of immunohistochemistry in diagnosing and classifying amyloidosis.
    • The findings suggest that localized lymph node amyloidosis can be of the immunoglobulin lambda light chain type.
    • Understanding the specific type of amyloid can guide further investigation and management, particularly regarding potential involvement of other organ systems like the respiratory tract.