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A simple method for estimating the ventilatory response to CO2 in infants.

J P Brady, M Durand, E McCann

The American Review of Respiratory Disease

|April 1, 1983

Summary

A new noninvasive method estimates carbon dioxide (CO2) response in infants by measuring oxygen (O2) levels. This technique accurately assesses ventilatory response to CO2 in uncooperative infants.

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Area of Science:

Pediatric Pulmonology
Respiratory Physiology

Background:

Assessing ventilatory response to carbon dioxide (CO2) is crucial for diagnosing respiratory control disorders.
Current methods often require patient cooperation, limiting their use in infants.

Purpose of the Study:

To evaluate a novel noninvasive method for estimating ventilatory response to CO2 in uncooperative infants.
To compare the efficacy of three indirect methods against the standard steady-state method.

Main Methods:

Compared changes in inspired minus alveolar partial pressure of oxygen (delta IAPO2), inspired minus alveolar partial pressure of carbon dioxide (delta AIPCO2), and transcutaneous partial pressure of oxygen (TcPO2).
Utilized the standard steady-state method as the reference for ventilatory response to CO2.
Conducted 21 comparisons in 7 preterm infants and 1 older child with central hypoventilation syndrome.

Main Results:

Changes in delta IAPO2 showed the best correlation with minute ventilation (r = 0.83, p < 0.001).
Changes in delta AIPCO2 demonstrated a weaker correlation (r = 0.66, p < 0.001).
No significant correlation was found between changes in TcPO2 and minute ventilation.

Conclusions:

Changes in inspired minus alveolar PO2 (delta IAPO2) provide a reliable, noninvasive method for estimating CO2 ventilatory response in uncooperative infants.
This method offers a valuable alternative to traditional techniques, particularly in challenging pediatric populations.
Delta AIPCO2 and TcPO2 are less suitable for estimating ventilatory response to CO2 in this context.

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