[Nucleus tuberis lateralis in the human brain. A pigmentarchitectonic study]

In the present article the shape of the nucleus tuberis lateralis and a hitherto unknown cell group in the human hypothalamus is described. Neurolipofuscin is selectively stained with aldehyde-fuchsin. This method enables the exact determination of the three dimensional shape of a griseum by using slices more than 500 mum thick. Differences in the distribution and amount of pigment within different types of nerve cells provide a basis for cellular demarcation and subdivision (pigmentarchitectonics). The intensely stained nucleus tuberis lateralis can be seen as consisting of a main lateral and a medial group. There are elevan cell groups which constantly occur. The individual range of their shapes causes a great variation in the shape of the lateral tuberal nucleus. It also has portions in the medial field of the hypothalamus: a pars suprafornicalis and 'mediale Streuzellen' ('medial scatter-cells'). Rostrally it extends almost to the chiasma with scattered irregularly occurring groups of cells. The amount of intracellular lipofuscin depends on the respective cell group and the age of the brain. By the age of 12 years the nucleus is already more intensely pigmented than the surrounding grisea. There is an indication of a tendency towards an aggregation of the cell groups with age. Connections between pigmentation and the phylogeny are discussed. Ventrally the nucleus tuberis lateralis is bounded by a hitherto undescribed heteromorphous cell group. It is clearly delimited and can be divided into a longish pars lateralis and a spherical pars medialis. Both parts consist of small as well as medium-sized cells which accumulate diffusely distributed granula of lipofuscin in adult brains. The name 'nucleus paratuberalis' is suggested for this griseum.