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Plasmapheresis in Rh hemolytic disease: the danger of amniocentesis
We have treated 25 women with poor obstetric histories and high levels of anti-Rh antibodies by plasmapheresis during pregnancy. One baby was Rs negative, but 13 of the remaining 24 babies survived. Most of the foetal deaths were associated with a rapid rise in antibody level uncontrollable by plasmapheresis and which followed either amniocentesis or intra-uterine transfusion. Plasmapheresis throughout pregnancy with early delivery and avoidance of amniocentesis is recommended.
We have treated 25 women with poor obstetric histories and high levels of anti-Rh antibodies by plasmapheresis during pregnancy. One baby was Rs negative, but 13 of the remaining 24 babies survived. Most of the foetal deaths were associated with a rapid rise in antibody level uncontrollable by plasmapheresis and which followed either amniocentesis or intra-uterine transfusion. Plasmapheresis throughout pregnancy with early delivery and avoidance of amniocentesis is recommended.