Related Experiment Videos
A murine anti-I-Ak monoclonal antibody recognizes human DR (I-E-like) antigens
A monoclonal antibody. H39-49.5, originally raised against the murine I-Ak antigen, recognizes a nonpolymorphic determinant on HLA-DR-like molecules from human cells. These HLA-DR-like molecules have been characterized by amino acid sequencing and have been found to be homologous to the murine I-E antigens rather than the murine I-A antigens. These results suggest a common origin for the murine I-E, I-A, and HLA-DR antigens and caution that serological cross-reactivity alone cannot be used to reliably establish the presence of structural homologues of I-E- or I-A-like molecules in other species.
A monoclonal antibody. H39-49.5, originally raised against the murine I-Ak antigen, recognizes a nonpolymorphic determinant on HLA-DR-like molecules from human cells. These HLA-DR-like molecules have been characterized by amino acid sequencing and have been found to be homologous to the murine I-E antigens rather than the murine I-A antigens. These results suggest a common origin for the murine I-E, I-A, and HLA-DR antigens and caution that serological cross-reactivity alone cannot be used to reliably establish the presence of structural homologues of I-E- or I-A-like molecules in other species.