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Middle Eastern intestinal lymphoma: a morphological and immunohistochemical study.

P Isaacson, H S Al-Dewachi, D Y Mason

    Journal of Clinical Pathology
    |May 1, 1983
    PubMed
    Summary

    This study analyzed Middle Eastern gastrointestinal lymphomas, identifying three main types: Burkitt, follicle center cell (FCC), and Mediterranean lymphoma (MTL). Mediterranean lymphoma

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    Area of Science:

    • Gastroenterology
    • Oncology
    • Immunology

    Background:

    • Gastrointestinal lymphomas in the Middle East present unique histological and immunohistochemical characteristics.
    • Understanding these variations is crucial for accurate diagnosis and treatment strategies.

    Purpose of the Study:

    • To classify Middle Eastern gastrointestinal lymphomas based on histology and immunoperoxidase staining.
    • To compare the immunophenotypes of these lymphomas with their European counterparts.
    • To elucidate the cellular origin of Mediterranean lymphoma (MTL).

    Main Methods:

    • Analysis of 31 Middle Eastern gastrointestinal lymphoma cases using conventional histology.
    • Immunoperoxidase staining with anti-immunoglobulin (Ig) and anti-J chain antisera on paraffin sections.
    • Categorization into Burkitt type, follicle center cell (FCC) lymphoma, and Mediterranean lymphoma (MTL).

    Main Results:

    • Three histological categories were identified: Burkitt type (8 cases), FCC lymphoma (15 cases), and MTL (3 cases).
    • FCC lymphomas showed distinct immunophenotypic differences from European cases, with isolated light chain or J chain detection.
    • Mediterranean lymphoma cases exhibited a plasma cell infiltrate positive for alpha and J chains, while invasive FCC-like cells were negative.
    • Intracellular alpha chain inclusions were noted in two FCC cases.

    Conclusions:

    • The three identified histological categories represent the primary types of gastrointestinal lymphoma in the Middle East.
    • Mediterranean lymphoma appears to be of follicle center cell origin, despite its distinct presentation.
    • Immunohistochemical analysis reveals significant variations in immunoglobulin expression within Middle Eastern lymphomas compared to European ones.

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