Related Experiment Video

Updated: Aug 10, 2026

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants
11:35

Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants

Published on: May 4, 2018

Current problems in the treatment of infective endocarditis due to Pseudomonas aeruginosa

M P Reyes, A M Lerner

    Reviews of Infectious Diseases
    |March 1, 1983
    PubMed

    Insights

    Pseudomonas infective endocarditis has high mortality. Combination therapy with high-dose aminoglycosides and beta-lactams, alongside surgery, improves outcomes for this serious infection.

    Area of Science:

    • Infectious Diseases
    • Cardiology
    • Pharmacology

    Background:

    • Pseudomonas infective endocarditis (PIE) presents a significant mortality challenge.
    • Tricuspid valve involvement is typically subacute, while mitral or aortic valve infections indicate more severe disease.
    • PIE cases can involve single or mixed Pseudomonas aeruginosa immunotypes.

    Purpose of the Study:

    • To evaluate the efficacy of combined beta-lactam and aminoglycoside antibiotics against Pseudomonas aeruginosa isolates.
    • To determine optimal antimicrobial regimens for PIE based on susceptibility and synergy testing.
    • To inform treatment strategies for both right-sided and left-sided PIE.

    Main Methods:

    • Antimicrobial susceptibility testing of 30 Pseudomonas aeruginosa isolates.
    • Synergy testing of beta-lactam and aminoglycoside antibiotic combinations.
    • Clinical data review for treatment outcomes in PIE.

    Main Results:

    • Azlocillin demonstrated the highest efficacy among tested beta-lactams when combined with aminoglycosides.
    • Netilmicin was the most effective aminoglycoside in combination therapy.
    • High-dose aminoglycoside and beta-lactam combinations proved efficacious, particularly for refractory right-sided endocarditis treated with valvulectomy.

    Conclusions:

    • Optimal treatment for refractory right-sided PIE involves medical therapy with valvulectomy.
    • Left-sided PIE necessitates immediate valve replacement coupled with a six-week course of high-dose combination antibiotics.
    • The effectiveness of newer beta-lactams like piperacillin may be compromised by beta-lactamase inactivation in Pseudomonas aeruginosa.

    More Related Videos

    A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection06:56

    A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection

    Published on: February 20, 2020

    Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae06:04

    Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae

    Published on: June 13, 2025

    Related Concept Videos

    Endocarditis I: Introduction01:25

    Endocarditis I: Introduction

    Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
    Endocarditis II: Clinical Features of Infective Endocarditis01:25

    Endocarditis II: Clinical Features of Infective Endocarditis

    Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
    Endocarditis III: Medical Management01:18

    Endocarditis III: Medical Management

    Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
    Endocarditis IV: Nursing Management01:29

    Endocarditis IV: Nursing Management

    Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Clinical Significance of Antibiotic Resistance01:25

    Clinical Significance of Antibiotic Resistance

    Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...