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Related Experiment Videos

Calcitonin-biochemistry and physiology.

R Ziegler

    Zeitschrift Fur Gastroenterologie. Verhandlungsband
    |January 1, 1976
    PubMed
    Summary

    Calcitonin (CT) is a mysterious hormone. While often seen as a calcium regulator, its diverse roles in reproduction and buffering across species suggest broader functions beyond inhibiting bone resorption.

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    Der Internist·1998

    Area of Science:

    • Endocrinology
    • Comparative Physiology
    • Molecular Biology

    Background:

    • Calcitonin (CT) is a protein hormone secreted by C-cells in the ultimobranchial body or thyroid glands.
    • Its primary proposed function is as a hypocalcemic agent, antagonizing parathyroid hormone by inhibiting osteolysis, particularly noted in small mammals like rats.

    Purpose of the Study:

    • To explore the multifaceted roles of calcitonin (CT) beyond its established hypocalcemic function.
    • To investigate the diverse physiological roles of CT across different vertebrate species, challenging a singular functional hypothesis.

    Main Methods:

    • Comparative analysis of calcitonin (CT) levels and functions across various species.
    • Review of existing literature on CT's role in calcium homeostasis, reproduction, and physiological buffering.

    Main Results:

    • In fish, CT levels correlate with the female reproductive cycle.
    • In amphibians, the ultimobranchial body's role in buffering capacity is linked to CT.
    • In birds, male sexual development is associated with elevated CT levels.

    Conclusions:

    • The function of calcitonin (CT) is more diverse than previously understood, extending beyond calcium regulation.
    • Species-specific roles of CT, particularly in reproduction and physiological buffering, highlight its complex evolutionary adaptations.

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