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Thyroid function in goitrous subjects with thyroxine binding globulin deficiency.

F P Callan, M J Duffy, G J Duffy

    Acta Endocrinologica
    |April 1, 1983
    PubMed
    Summary
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    Thyroxine binding globulin (TBG) deficiency and euthyroid goitre can co-exist but are not solely linked. TBG deficiency may worsen goitre in susceptible individuals, with free triiodothyronine index best reflecting euthyroid status.

    Area of Science:

    • Endocrinology
    • Genetics

    Background:

    • Thyroxine binding globulin (TBG) deficiency and euthyroid goitre are distinct endocrine conditions.
    • Familial co-occurrence of these conditions suggests potential, but not exclusive, genetic links.

    Purpose of the Study:

    • To investigate the relationship between TBG deficiency and euthyroid goitre within a family.
    • To determine if TBG deficiency directly causes or influences goitre development.
    • To identify reliable markers for assessing thyroid status in TBG-deficient individuals.

    Main Methods:

    • Clinical examination of family members.
    • Assessment of thyroid hormone levels, including free triiodothyronine index and TSH.
    • Evaluation of TBG levels and thyroid morphology.

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    Main Results:

    • Both TBG deficiency and euthyroid goitre were present in some family members, but not all.
    • Goitre development was not solely attributable to TBG deficiency.
    • Individuals with TBG deficiency showed the largest goitres, suggesting an exacerbating role.
    • The free triiodothyronine index accurately reflected euthyroid status in TBG-deficient patients.

    Conclusions:

    • TBG deficiency and euthyroid goitre are not directly causative of each other.
    • TBG deficiency may act as a modifier, enhancing goitre development in genetically predisposed individuals.
    • The free triiodothyronine index is a reliable indicator of euthyroid status in TBG deficiency.