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Neuroendocrine abnormalities in bulimia.

H E Gwirtsman, P Roy-Byrne, J Yager

    The American Journal of Psychiatry
    |May 1, 1983
    PubMed
    Summary
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    Bulimic patients frequently exhibit neuroendocrine abnormalities, including issues with cortisol suppression and thyrotropin-releasing hormone (TRH) tests. These findings suggest shared neurochemical links between eating disorders and affective disorders.

    Area of Science:

    • Neuroendocrinology
    • Psychiatry
    • Eating Disorders

    Background:

    • Neuroendocrine abnormalities are documented in anorexia nervosa.
    • The role of weight in these abnormalities is debated.
    • Bulimia nervosa is a complex eating disorder with potential neurochemical underpinnings.

    Purpose of the Study:

    • To investigate neuroendocrine function in patients with bulimia nervosa.
    • To explore the relationship between clinical variables, family history, and neuroendocrine function in bulimia nervosa.
    • To determine if neuroendocrine abnormalities in eating disorders are weight-dependent.

    Main Methods:

    • Assessment of clinical variables and family history in 18 bulimic patients.
    • Evaluation of cortisol suppression response.

    Related Experiment Videos

  • Administration of thyrotropin-releasing hormone (TRH) tests.

    • Main Results:

    • 67% of patients (12/18) displayed abnormal cortisol suppression.
    • 80% of patients (8/10) showed blunted thyrotropin-releasing hormone (TRH) test results.
    • Neuroendocrine abnormalities were observed irrespective of patient weight.

    Conclusions:

    • Neuroendocrine abnormalities in eating disorders are not solely due to low weight.
    • Bulimia nervosa shares neurochemical similarities with affective disorders.
    • Further research into shared neurochemical pathways is warranted.