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Related Experiment Videos

Oral testosterone, a reappraisal.

P R Daggett, M J Wheeler, J D Nabarro

    Hormone Research
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Oral free testosterone in hypogonadal men showed unreliable absorption and a double-peak effect, suggesting variable particle absorption. High doses make this oral form impractical for routine androgen replacement therapy.

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    Area of Science:

    • Endocrinology
    • Pharmacokinetics

    Background:

    • Hypogonadism requires androgen replacement therapy.
    • Oral testosterone formulations aim for convenient administration.

    Purpose of the Study:

    • To evaluate the pharmacokinetic and clinical effects of oral microparticulate free testosterone.
    • To assess the suitability of oral free testosterone for routine androgen replacement.

    Main Methods:

    • Administered 200 mg oral microparticulate free testosterone to 6 hypogonadal men.
    • Monitored plasma testosterone levels and observed clinical/biochemical effects over 2 months.
    • Compared oral free testosterone to standard androgen replacement.

    Main Results:

    • Observed a double-peak plasma testosterone profile after a single 200-mg dose.

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  • Indicated variable absorption rates potentially due to different particle sizes.
  • Found absorption to be unreliable for routine clinical use.
  • Required large doses to achieve therapeutic levels.

    • Conclusions:

    • Oral microparticulate free testosterone exhibits unpredictable absorption.
    • The high dosage requirements render this oral formulation impractical for hypogonadism treatment.
    • Further research into optimized oral testosterone delivery systems is warranted.