[Increase in blood uric acid induced by indomethacin in hens or chickens]

Indomethacin (2.5 mg/kg) causes a rapid increase in plasma urate concentrations and at 5 mg/kg I.M. may cause death by deposition of urates in the viscera (visceral gout). This increase is probably a consequence of decreased renal tubular urate secretion. The sensitivity to indomethacin varies either according to the strain of Bird or the physiological status: Hens appear more sensitive during egg formation.