Solitary intracranial plasmacytoma

Area of Science:

• Neuropathology
• Oncology
• Immunology

Background:

• Solitary intracranial plasmacytoma (SIP) is a rare plasma cell tumor affecting the central nervous system.
• Understanding the clinical, radiological, and pathological features of SIP is crucial for diagnosis and management.

Observation:

• A rare case of solitary intracranial plasmacytoma (SIP) originating from the tentorium is presented.
• The patient exhibited abnormal IgG lambda monoclonal protein in serum and cerebrospinal fluid (CSF).
• Amyloid deposits with crystalloid morphology were observed within the tumor tissue and vasculature.

Findings:

• Microscopic examination revealed mature plasma cells as the primary tumor component.
• Immunohistochemistry confirmed a monoclonal population of plasma cells producing a single immunoglobulin type.
• The abnormal IgG lambda protein resolved after tumor debulking and radiation therapy.

Implications:

• This case underscores the importance of correlating clinical, laboratory, and pathological findings in diagnosing and managing SIP.
• The resolution of monoclonal protein suggests a potential marker for treatment response in intracranial plasmacytomas.
• Further research into the pathogenesis and optimal treatment of SIP is warranted based on such case reports.