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Related Experiment Videos

Testis function in rhesus monkeys treated with a contraceptive steroid formulation.

L L Ewing, R C Cochran, R J Adams

    Contraception
    |April 1, 1983
    PubMed
    Summary

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    Testosterone and estradiol implants in rhesus monkeys suppressed luteinizing hormone (LH) and testicular function, reducing sperm motility. This hormonal suppression occurred at doses mimicking natural levels in male monkeys.

    Area of Science:

    • Reproductive Endocrinology
    • Primate Physiology

    Background:

    • Hormonal regulation of male reproductive function is complex.
    • Understanding the effects of exogenous steroids on primate reproductive systems is crucial for contraception development.

    Purpose of the Study:

    • To investigate the effects of sustained testosterone and estradiol administration on reproductive parameters in male rhesus monkeys.
    • To determine if physiological levels of these steroids can suppress testicular function.

    Main Methods:

    • Male rhesus monkeys received subcutaneous polydimethylsiloxane implants delivering testosterone (100 µg/kg/day) and estradiol (0.5 µg/kg/day) for 13 months.
    • Hormonal levels (LH, FSH, testosterone, estradiol) and sperm parameters (motility) were monitored throughout the study.
    Keywords:
    AndrogensAnimals, LaboratoryBiologyClinical ResearchContraceptionContraception ResearchEndocrine SystemEstradiol--administraction and dosageEstrogensExaminations And DiagnosesFamily PlanningFollicle Stimulating Hormone--analysisGenitaliaGenitalia, MaleGerm CellsGonadotropinsGonadotropins, PituitaryHormonesLaboratory Examinations And DiagnosesLaboratory ProceduresLuteinizing Hormone--analysisMale ContraceptionMetabolic EffectsPhysiologyResearch MethodologySemen--analysisSeminal VesiclesSpermatozoa--analysisTestis--changesTestosterone--administraction and dosageUrogenital System

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    Main Results:

    • The steroid regimen significantly inhibited luteinizing hormone (LH) secretion but not follicle-stimulating hormone (FSH).
    • Testicular production of testosterone and estradiol was suppressed.
    • A drastic reduction in vigorously motile spermatozoa was observed in ejaculates.

    Conclusions:

    • Sustained administration of testosterone and estradiol at physiological levels effectively suppresses key aspects of male reproductive function in rhesus monkeys.
    • This hormonal suppression impacts gonadotropin secretion and sperm production, suggesting potential for hormonal male contraception.