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Related Experiment Videos

STS 557 as an interceptive in baboons.

A Komor, N P Goncharov, K Schubert

    Experimental and Clinical Endocrinology
    |February 1, 1983
    PubMed
    Summary
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    STS 557 demonstrated high interceptive activity in a non-human primate model when administered postcoitally. This novel contraceptive agent did not suppress ovulation, offering a potential new option for emergency contraception.

    Area of Science:

    • Reproductive Endocrinology
    • Primate Reproductive Physiology
    • Pharmacology

    Background:

    • Emergency contraception aims to prevent unintended pregnancies after unprotected intercourse.
    • Levonorgestrel is a commonly used oral contraceptive, but its efficacy can vary.
    • Novel compounds are needed to improve contraceptive options and address unmet needs.

    Purpose of the Study:

    • To evaluate the interceptive efficacy of STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one) in a non-human primate model.
    • To compare the efficacy of STS 557 with levonorgestrel when administered postcoitally.
    • To investigate the mechanism of action of STS 557, specifically its effect on ovulation and progesterone levels.

    Main Methods:

    • Oral administration of STS 557 or levonorgestrel (0.4 mg/animal) after mating periods of 18 hours or 6 hours.

    Related Experiment Videos

  • Monitoring of pregnancy rates in treated animals compared to controls.
  • Assay of postovulatory plasma progesterone levels.
  • Assessment of menstrual cycle characteristics following repeated STS 557 administration.

    • Main Results:

    • Postcoital STS 557 administration after a 6-hour mating period resulted in a low pregnancy rate (4%) compared to controls (30%).
    • Levonorgestrel also showed reduced pregnancy rates (11.5% after 6h mating) compared to controls (30%).
    • STS 557 did not suppress the postovulatory rise in plasma progesterone, indicating it does not inhibit ovulation.

    Conclusions:

    • Postcoital STS 557 exhibits significant interceptive activity in this primate model, suggesting potential as an emergency contraceptive.
    • STS 557's mechanism appears to be post-fertilization, as it does not inhibit ovulation.
    • Further research is warranted to explore the full contraceptive potential and safety profile of STS 557.