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SeHCAT absorption: a simple test of ileal dysfunction.

E A Fagan, V S Chadwick, I M Baird

    Digestion
    |January 1, 1983
    PubMed
    Summary
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    A new selenium-labelled synthetic bile salt (SeHCAT) is a safe and simple screening tool for ileal dysfunction in inflammatory bowel disease (IBD) patients. It offers practical advantages over the Schilling test for assessing ileal function.

    Area of Science:

    • Gastroenterology
    • Nuclear Medicine
    • Diagnostic Imaging

    Background:

    • Ileal dysfunction is a common complication in inflammatory bowel disease (IBD).
    • Accurate assessment of ileal function is crucial for managing IBD patients.
    • Existing diagnostic tests for ileal dysfunction have limitations.

    Purpose of the Study:

    • To evaluate the efficacy of a novel selenium-labelled synthetic bile salt, SeHCAT (taurine conjugate of 23-[75Se]-25-homocholic acid), as a diagnostic test for ileal dysfunction.
    • To compare the performance of SeHCAT with established tests for ileal function, including the Schilling test, vitamin B12 absorption, cholylglycine-1-14C breath test, and fecal isotope excretion.

    Main Methods:

    • Twenty IBD patients and 10 healthy controls participated in the study.

    Related Experiment Videos

  • SeHCAT (7-day whole body retention) was administered and measured.
  • Results were compared with vitamin B12 absorption tests and cholylglycine breath test.

    • Main Results:

    • SeHCAT demonstrated clear differentiation between normal subjects and patients with ileal disease/resection, with no overlap in 7-day retention values.
    • The Schilling test showed higher sensitivity, distinguishing between limited and extensive ileal disease.
    • An unexpected increase in SeHCAT retention was observed in patients with colonic IBD.

    Conclusions:

    • The 7-day SeHCAT retention test is a safe, simple, and effective screening tool for detecting ileal dysfunction in IBD.
    • SeHCAT offers practical advantages over the Schilling test for routine clinical use.
    • Further investigation is warranted for the observed SeHCAT retention patterns in colonic IBD.