[Use of methods of 2-dimensional electrophoresis in population genetics]

The review of literature on application of the methods of two-dimensional electrophoresis according to O'Farrel, in population genetics and in some adjacent fields of biology, is presented. Resolution capacities of both conventional and two-dimensional electrophoresis are briefly characterized. Data on application of two-dimensional electrophoresis methods for evaluation the degree of inter- and intraspecific variability, for detection and characterization of mutations, as well as for analysis of molecular mechanisms of inborn pathology are reviewed.