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Studies on the metabolic conversion of ascorbate.

K Schmidt, H Oberritter, G Bruchelt

    International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
    |January 1, 1983
    PubMed
    Summary
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    Guinea pigs metabolize ascorbic acid to carbon dioxide faster than rats, though total excretion is similar. This rapid metabolism in guinea pigs, unlike rats, may stem from liver recirculation rather than intestinal breakdown.

    Area of Science:

    • Biochemistry
    • Animal Physiology
    • Nutritional Science

    Background:

    • Ascorbic acid (vitamin C) is essential, but its metabolism varies across species.
    • Understanding species-specific metabolic pathways is crucial for nutritional research.

    Purpose of the Study:

    • To investigate the metabolic fate of ascorbic acid in guinea pigs compared to rats.
    • To elucidate the mechanisms and tissues involved in ascorbic acid metabolism.

    Main Methods:

    • Oral administration of (1-14C)ascorbic acid to guinea pigs and rats.
    • Measurement of (14C)carbon dioxide exhalation over time.
    • In vitro incubation of ascorbic acid with tissue homogenates and microbial flora.
    • Analysis of metabolites using analytical isotachophoresis.

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    Main Results:

    • Guinea pigs exhibited rapid (14C)carbon dioxide exhalation from ascorbic acid (peak 30 min) compared to rats (peak 2-3 h).
    • Total excretion of radioactivity was comparable between species.
    • No significant CO2 production was observed from tissue homogenates or gut flora, suggesting non-enzymatic metabolism.
    • Ascorbic acid appears stable, while its derivatives dehydroascorbate and 2,3-diketogulonic acid degrade rapidly.

    Conclusions:

    • The rapid excretion of (14C)carbon dioxide in guinea pigs is likely due to non-enzymatic reactions in the liver, possibly involving enhanced recirculation.
    • Ascorbic acid metabolism to CO2 does not appear to involve dehydroascorbic acid as an intermediate.
    • Presystemic metabolism in the intestinal wall is unlikely to be the primary route for ascorbic acid breakdown to CO2.