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Methanethiol metabolism in the rat.

R F Derr, K Draves

    Research Communications in Chemical Pathology and Pharmacology
    |March 1, 1983
    PubMed
    Summary

    Methanethiol contributes to hepatic failure and coma. The body eliminates methanethiol sulfur as urinary sulfate, but rats with hepatic coma excrete significantly less sulfate.

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    Area of Science:

    • Biochemistry
    • Toxicology
    • Hepatology

    Background:

    • Methanethiol is implicated in human hepatic failure.
    • The combined effect of methanethiol, ammonia, and octanoate can induce coma in experimental hepatic necrosis.

    Purpose of the Study:

    • To investigate the metabolic fate of methanethiol in the context of hepatic failure.
    • To assess the urinary sulfate excretion as an indicator of methanethiol metabolism.

    Main Methods:

    • Administration of methanethiol to rats.
    • Monitoring of urinary sulfate excretion over time.
    • Comparison of sulfate excretion in healthy rats versus rats with experimental hepatic coma.

    Main Results:

    • Methanethiol sulfur is primarily excreted as urinary sulfate, with 94% eliminated within 21 hours.
    • Rats induced into hepatic coma (via octanoate or hepatic necrosis) excreted minimal amounts of urinary sulfate.

    Conclusions:

    • The impaired sulfate excretion in hepatic coma suggests a disruption in methanethiol detoxification pathways.
    • Methanethiol metabolism and its role in hepatic encephalopathy warrant further investigation.

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